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#1 There are many things that determine the lifespan of an organism, such as its genetics, phylogeny, mutations, and life history. However, the biggest role probably has to do with the ecological niche.
#2 Free radicals are atoms or molecules with an unpaired electron in their outer layer. They are very reactive and cause oxidative damage. Antioxidants and other reducing agents can lower this oxidation.
#3 The ability to cope with oxidative stress and other stressors is compromised in aging, which makes you more vulnerable to free radicals as you get older. Taking lots of antioxidants and reducing oxidative stress with supplements has failed to be effective in fighting disease.
#4 The mitochondria are the most important organelles in your body as they govern everything related to energy metabolism and cellular homeostasis. If your mitochondria are dysfunctional, you will not only speed up aging but also feel more tired, exhausted, and lethargic.
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